CAFFEINE AND PERFORMANCE IN ENDURANCE SPORTS: A SYSTEMATIC LITERATURE REVIEW

Authors

  • José Dalvo Maia Neto Author
  • Heraldo Simões Ferreira Author
  • Marcos Vinícius Assunção Neto Author

DOI:

https://doi.org/10.56238/ERR01v11n1-009

Keywords:

Caffeine, Athletic Performance, Endurance Sports, Nutritional Supplementation, Ergogenic Aids, Exercise Physiology

Abstract

Introduction: Caffeine is one of the most studied and widely used ergogenic substances by endurance athletes, with consistent evidence of improved physical performance. Objective: To conduct a systematic review of the literature on the effects of caffeine supplementation on the performance of athletes in endurance sports, analyzing dosages, timing of administration, mechanisms of action, and possible adverse effects. Methods: A systematic search was performed in PubMed, Scopus, Web of Science, and SPORTDiscus databases, using the descriptors 'caffeine', 'endurance', 'performance', 'supplementation', and 'athletes'. Randomized clinical trials published between 2010 and 2024 involving endurance athletes were included. Results: 47 studies met the inclusion criteria. Caffeine supplementation (3-6 mg/kg) significantly improved performance in endurance events (p<0.05), with an average increase of 2-4% in time to exhaustion and a 1-3% reduction in race time. Mechanisms include adenosine receptor antagonism, increased fatty acid mobilization, reduced perception of effort, and improved muscle contractility. Adverse effects were reported at doses above 9 mg/kg. Conclusion: Caffeine is an effective and safe ergogenic aid for endurance athletes when used at doses of 3-6 mg/kg, administered 45-60 minutes before exercise. Future studies should investigate individual variability in caffeine response and supplementation periodization strategies.

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References

1. Goldstein ER, Ziegenfuss T, Kalman D, et al. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr. 2010;7(1):5.

2. Nehlig A. Is caffeine a cognitive enhancer? J Alzheimers Dis. 2010;20(S1):S85-S94.

3. World Anti-Doping Agency. The World Anti-Doping Code: The 2004 Prohibited List International Standard. Montreal: WADA; 2004.

4. Del Coso J, Muñoz G, Muñoz-Guerra J. Prevalence of caffeine use in elite athletes following its removal from the World Anti-Doping Agency list of banned substances. Appl Physiol Nutr Metab. 2011;36(4):555-561.

5. Joyner MJ, Coyle EF. Endurance exercise performance: the physiology of champions. J Physiol. 2008;586(1):35-44.

6. Davis JK, Green JM. Caffeine and anaerobic performance: ergogenic value and mechanisms of action. Sports Med. 2009;39(10):813-832.

7. Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807.

8. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008;33(6):1319-1334.

9. Wickham KA, Spriet LL. Administration of caffeine in alternate forms. Sports Med. 2018;48(Suppl 1):79-91.

10. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

11. Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83(8):713-721.

12. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51(1):83-133.

13. Ribeiro JA, Sebastião AM. Caffeine and adenosine. J Alzheimers Dis. 2010;20(S1):S3-S15.

14. Spriet LL. Exercise and sport performance with low doses of caffeine. Sports Med. 2014;44(Suppl 2):S175-S184.

15. Tallis J, Duncan MJ, James RS. What can isolated skeletal muscle experiments tell us about the effects of caffeine on exercise performance? Br J Pharmacol. 2015;172(15):3703-3713.

16. Doherty M, Smith PM. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005;15(2):69-78.

17. Robertson D, Wade D, Workman R, Woosley RL, Oates JA. Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest. 1981;67(4):1111-1117.

18. Guest N, Corey P, Vescovi J, El-Sohemy A. Caffeine, CYP1A2 genotype, and endurance performance in athletes. Med Sci Sports Exerc. 2018;50(8):1570-1578.

19. Grgic J, Pickering C, Bishop DJ, et al. CYP1A2 genotype and acute ergogenic effects of caffeine intake on exercise performance: a systematic review. Eur J Nutr. 2020;59(8):3271-3290.

20. Beaumont R, Cordery P, Funnell M, Mears S, James L, Watson P. Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine. J Sports Sci. 2017;35(19):1920-1927.

21. Gonçalves LS, Painelli VS, Yamaguchi G, et al. Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation. J Appl Physiol. 2017;123(1):213-220.

22. Mielgo-Ayuso J, Marques-Jiménez D, Refoyo I, Del Coso J, León-Guereño P, Calleja-González J. Effect of caffeine supplementation on sports performance based on differences between sexes: a systematic review. Nutrients. 2019;11(10):2313.

23. Paton CD, Hopkins WG. Competitive performance of elite Olympic-distance triathletes: reliability and smallest worthwhile enhancement. Sportscience. 2005;9:1-5.

24. Koppelstaetter F, Poeppel TD, Siedentopf CM, et al. Caffeine and cognition in functional magnetic resonance imaging. J Alzheimers Dis. 2010;20(S1):S71-S84.

25. Talanian JL, Spriet LL. Low and moderate doses of caffeine late in exercise improve performance in trained cyclists. Appl Physiol Nutr Metab. 2016;41(8):850-855.

26. Guest NS, VanDusseldorp TA, Nelson MT, et al. International society of sports nutrition position stand: caffeine and exercise performance. J Int Soc Sports Nutr. 2021;18(1):1.

27. Drake C, Roehrs T, Shambroom J, Roth T. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. J Clin Sleep Med. 2013;9(11):1195-1200.

Published

2026-01-08

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Articles

How to Cite

CAFFEINE AND PERFORMANCE IN ENDURANCE SPORTS: A SYSTEMATIC LITERATURE REVIEW. (2026). ERR01, 11(1), e11691. https://doi.org/10.56238/ERR01v11n1-009